Portrait of the Inflammatory Response to Radioiodine Therapy in Female Patients with Differentiated Thyroid Cancer with/without Type 2 Diabetes Mellitus

No clinical studies have investigated the effect of radioiodine (131I)-targeted therapy on neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) as inflammatory response markers in patients with differentiated thyroid cancer (DTC) associated type 2 diabetes mellitus (T2DM) obesity. This study aimed to assess relationship between blood radioactivity, body mass index (BMI), peripheral cells three days after 131I intake 56 female without T2DM (DTC/−T2DM) vs. 24 (DTC/+T2DM). Blood measured intake, was significantly lower DTC/+T2DM than DTC/−T2DM (0.7 mCi 1.5 mCi, p < 0.001). The radioactivity BMI (r = 0.83, 0.001), NLR 0.53, 0.008), 0.58, 0.003) indicates a possible connection bloodstream uptake T2DM-specific chronic inflammation. In T2DM, has immunosuppressive effects, leading increased (19.6%, 0.009) PLR (39.1%, 0.002). On contrary, inflammation context amplifies immune metabolism, drop (10%, 0.032) (13.4%, 0.021). Our results show that, DTC/+T2DM, bidirectional crosstalk neutrophils obesity may limit bloodstream. Considering therapy, two groups can be seen synchronous portrait sides. explanation could lie different radiosensitivity T B lymphocytes, lymphocytes being predominant and, most likely, T2DM.